2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid
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- CAS-Nr.
- 62-51-1
- Bezeichnung:
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid
- Englisch Name:
- METHACHOLINE CHLORIDE
- Synonyma:
- amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
- CBNumber:
- CB2316248
- Summenformel:
- C8H18ClNO2
- Molgewicht:
- 195.69
- MOL-Datei:
- 62-51-1.mol
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2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid Eigenschaften
- Schmelzpunkt:
- 171-173 °C(lit.)
- Dichte
- 1.1028 (rough estimate)
- Brechungsindex
- 1.5790 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- H2O: 50 mg/mL, clear, colorless
- Aggregatzustand
- powder
- Farbe
- White to Almost white
- PH
- 3.0～7.0 (50g/l, 25℃)
- Wasserl?slichkeit
- almost transparency
- Merck
- 14,5940
- BRN
- 4162373
- Stabilit?t:
- Unstable - moisture sensitive. Incompatible with oxidizing agents.
- LogP
- -3.957 (est)
- CAS Datenbank
- 62-51-1
- EPA chemische Informationen
- 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
BR5250000 |
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| F |
3-10-21 |
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| HS Code |
29239000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
colourless to white crystalline powder with a slight
Verwenden
antihypertensive, antianginal
Allgemeine Beschreibung
Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective
muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the
S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
l?uterung methode
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 179)Lieferanten
62-51-1(2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid)Verwandte Suche:
- beta-methylacetylcholinechloride
- mecholyl
- (2-ACETOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE
- 1-PROPANAMINIUM 2-(ACETYLOXY)-N,N,N-TRIMETHYL CHLORIDE
- O-ACETYL-BETA-METHYLCHOLINE CHLORIDE
- TRIMETHYL-B-ACETOXYPROPYLAMMONIUM CHLORIDE
- TRIMETHYL-BETA-ACETOXYPROPYLAMMONIUM CHLORIDE
- 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminiuchloride
- amechol
- ammonium,(2-hydroxypropyl)trimethyl-,chloride,acetate
- Mecholine chloride
- O-Acetyl-β-methylcholine chloride
- Acetyl-beta-methylcholine chloride,98%
- Acetyl b-methylcholine chloride 98%+
- O-Acetyl-beta-methylcholine Chloride
Mecholyl Chloride
- 2-acetoxy-N,N,N-triMethylpropan-1-aMiniuM chloride
- Methacholine Chloride (AS)
- Methacholine Chloride (500 mg) (AS)
- methacholiniumchloride
- methylacetylcholine
- ACETYL-B-METHYLCHOLINE CHLORIDECRYSTALLI NE
- METHACHOLINE CHLORIDE ACETYL-B-METHYLCHO LIN
- METHACHOLINE CHLORIDE 98+%
- METHACHOLINE CHLORIDE CRYSTALLINE
- Methacloline
- METHACHOLINECHLORIDE,CRYSTAL
- METHACHOLINECHLORIDE,CRYSTAL,USP
- METHACHOLINECHLORIDE,HIGHPURITY
- Methacoline chloride
- (2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride
- ACETYL-2-METHYLCHOLINE CHLORIDE
- ACETYL-BETA-METHYLCHOLINE CHLORIDE
- ACETYL-B-METHYLCHOLINE CHLORIDE
- METHACHOLINE CHLORIDE
- MECHOLYL CHLORIDE
- (2-HYDROXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE ACETATE
- 2-(ACETYLOXY)-N,N,N-TRIMETHYL-1-PROPANAMINIUM CHLORIDE
- 2-acetyloxypropyl(trimethyl)ammonium chloride
- MethacholineChloride>
- Acetyl-β-methylcholine chloride
- METHACHOLINE CHLORIDE USP/EP/BP
- Methacholine Chloride (AS) (1396364)
- O-Acetyl-β-methylcholine Chloride
- Acetyl-β-methylcholine chloride
- Methacholine Chloride, 10 mM in DMSO
- 62-51-1
- C8H18NO2Cl
- C8H18ClNO2
- CH3COOCHCH3CH2NClCH33
- Ammonium Chlorides (Quaternary)
- Quaternary Ammonium Compounds
- LOPRESSOR
- inhibitor
- Ammonium Chlorides (Quaternary)
- Quaternary Ammonium Compounds
