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5’O-Tritylinosine

5’O-Tritylinosine Struktur
4152-77-6
CAS-Nr.
4152-77-6
Englisch Name:
5’O-Tritylinosine
Synonyma:
KIN-59;5'-O-Trt-rI;5'-O-Trt-rI;5’O-Tritylinosine;5’-O-Tritylinosine;Inosine, 5'-O-(triphenylmethyl)-;5'-O-tritylinosine-2'-deoxyinosine
CBNumber:
CB22701680
Summenformel:
C29H26N4O5
Molgewicht:
510.54
MOL-Datei:
4152-77-6.mol

5’O-Tritylinosine Eigenschaften

L?slichkeit
DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL
Aggregatzustand
A crystalline solid
Farbe
White to off-white

Sicherheit

5’O-Tritylinosine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice.

Verwenden

5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase.

5’O-Tritylinosine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5’O-Tritylinosine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 5’O-Tritylinosine
  • KIN-59
  • Inosine, 5'-O-(triphenylmethyl)-
  • 5'-O-tritylinosine-2'-deoxyinosine
  • 5'-O-Trt-rI
  • 5'-O-Trt-rI
  • 5’-O-Tritylinosine
  • 4152-77-6
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