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Histone Acetyltransferase Inhibitor IV, CPTH2

Histone Acetyltransferase Inhibitor IV, CPTH2 Struktur
357649-93-5
CAS-Nr.
357649-93-5
Englisch Name:
Histone Acetyltransferase Inhibitor IV, CPTH2
Synonyma:
CPTH2;CPTH2, 10 mM in DMSO;Histone Acetyltransferase Inhibitor IV, CPTH2;Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone;Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole , CPTH2
CBNumber:
CB22602855
Summenformel:
C14H14ClN3S
Molgewicht:
291.8
MOL-Datei:
357649-93-5.mol

Histone Acetyltransferase Inhibitor IV, CPTH2 Eigenschaften

Schmelzpunkt:
190-191 °C
Siedepunkt:
460.3±37.0 °C(Predicted)
Dichte
1.38±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
powder
pka
14.57±0.20(Predicted)
Farbe
white to beige
Wasserl?slichkeit
Water: < 0.1 mg/mL (insoluble)
Sensitive 
Light Sensitive
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Sicherheit

WGK Germany  nwg

Histone Acetyltransferase Inhibitor IV, CPTH2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo.

Allgemeine Beschreibung

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Histone Acetyltransferase Inhibitor IV, CPTH2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1-Cyclopentylidenethiosemicarbazide Brommethyl-p-chlorphenylketon Cyclopentanon

Downstream Produkte

Histone Acetyltransferase Inhibitor IV, CPTH2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 82)Lieferanten
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VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826
 market@aladdin-e.com China 25003 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
info@tsbiochem.com China 8065 58

357649-93-5()Verwandte Suche:

  • Histone Acetyltransferase Inhibitor IV, CPTH2
  • CPTH2
  • Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
  • Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone
  • 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
  • 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole
  • 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole , CPTH2
  • CPTH2, 10 mM in DMSO
  • 357649-93-5
  • HAT Inhibitor IV, Gcn5p Inhibitor, CPTH2
  • Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
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