Anti-LYN antibody, Mouse monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-LYN antibody, Mouse monoclonal is suitable for immunoblotting and immunocytochemistry.
Allgemeine Beschreibung
Monoclonal Anti-LYN (mouse IgG2b isotype) is derived from the hybridoma LYN-27 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide. The LYN gene is mapped to human chromosome 8q12.1. Lyn is an important Src-family kinase (SFK) expressed in B lymphocytes. Lyn contains an N-terminal unique domain, SH3, SH2, and tyrosine kinases domain. Lyn exists as two isoforms, p53 and p56, arising from alternate splicing of exon 2.
Biochem/physiol Actions
The tyrosine-protein kinase Lyn acts as both a positive and negative regulator of B cell receptor signaling pathways. Interestingly, it is a critical mediator in many pathways of B cell activation through the cluster of differentiation 19 (CD19) and CD180. It is shown that Lyn activity is associated with the pathological conditions arising due to the LYN gene related loss of function and gain of function in mice. It might cause lethal antibody-mediated autoimmune diseases and myeloid neoplasia in mice.
Anti-LYN antibody, Mouse monoclonal Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
