Ethyl 2-chloropyrimidine-5-carboxylate
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- CAS-Nr.
- 89793-12-4
- Englisch Name:
- Ethyl 2-chloropyrimidine-5-carboxylate
- Synonyma:
- EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester
- CBNumber:
- CB1547225
- Summenformel:
- C7H7ClN2O2
- Molgewicht:
- 186.6
- MOL-Datei:
- 89793-12-4.mol
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Ethyl 2-chloropyrimidine-5-carboxylate Eigenschaften
- Schmelzpunkt:
- 52-60℃
- Siedepunkt:
- 80℃/760mm
- Dichte
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- soluble in Methanol
- pka
- -3.05±0.22(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Light yellow
- InChI
- InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
- InChIKey
- IEMKQRSOAOPKRJ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(OCC)=O)C=N1
- CAS Datenbank
- 89793-12-4
Ethyl 2-chloropyrimidine-5-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to light yellow liquid
Verwenden
Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.
Synthese
A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).
Ethyl 2-chloropyrimidine-5-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ethyl 2-chloropyrimidine-5-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 254)Lieferanten
89793-12-4()Verwandte Suche:
- Ethyl 2-chloropyrimidine-5-carboxylate ,97%
- 2-chloro-pyrimidine-5-carboxylic acid ethyl ester
- 2-Chloro-5-(ethoxycarbonyl)pyrimidine
- 5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester
- ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
- PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester
- 2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine
- Ethyl 2-Chlorpyrimidine-5-carboxylate
- 2-chloro-pyriMidine-5-carboxylate
- ETHYL2-CHLOROPYRIMI
- EOS-60350
- 5-Pyrimidinecarboxylic acid, 2-chloro-, ethyl ester (7CI, 9CI, ACI)
- 2-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI)
- 89793-12-4
- Heterocycle-Pyrimidine series
