Anti-Pleckstrin homology domain containing, family A member 7 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-PLEKHA7 antibody produced in rabbit has been used in immunofluorescence and immunoblotting.
Allgemeine Beschreibung
Pleckstrin homology domain containing A7 (PLEKHA7) is a junctional protein, encoded by the gene mapped to human chromosome 11. PLEKHA7 belongs to the group of zonula adherens (ZA) proteins. The encoded protein is localized strictly at apical adherens junction (AJ) in epithelial cells.
Biochem/physiol Actions
Pleckstrin homology domain containing A7 (PLEKHA7) functions as a zonula adherens (ZA) stabilizer and as an adaptor protein, which helps in binding the adherens junctions (AJs) to the minus ends of the microtubules. The protein controls miRNA-mediated cell growth by interacting with the microprocessor complex at the apical ZA. Mutation in the gene leads to blood pressure and/or hypertension. Downregulated expression of PLEKHA7 has been observed in high grade ductal carcinomas and in lobular carcinomas.
Anti-Pleckstrin homology domain containing, family A member 7 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
