15-deoxy-Δ12,14-Prostaglandin J2-d4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
15-
deoxy-
Δ
12,14-
PGJ
2-
d
4 contains four deuterium atoms at the 3, 3'', 4, and 4'' positions. It is intended for use as an internal standard for the quantification of 15-
deoxy-
Δ
12,14-
PGJ
2 by GC-
or LC-
mass spectrometry. 15-
deoxy-
Δ
12,14-
Prostaglandin J
2 (15-
deoxy-
Δ
12,14-
PGJ
2) is a metabolite of PGJ
2. 15-
deoxy-
Δ
12,14-
PGJ
2 is formed from PGD
2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC
50 of 2 μM in a murine chimera system. 15-
deoxy-
Δ
12,14-
PGJ
2 is more potent than PGD
2, Δ
12-
PGJ
2, and PGJ
2 in stimulating lipogenesis in C3H10T1/2 cells. The EC
50 for induction of adipocyte differentiation in cultured fibroblasts is 7 μM.
15-deoxy-Δ12,14-Prostaglandin J2-d4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte