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Semustine

Semustine Struktur
13909-09-6
CAS-Nr.
13909-09-6
Englisch Name:
Semustine
Synonyma:
Me-CCNU;icig1110;Semustin;SEMUSTINE;ICIG 1110;NSC 95441;nsc-95441;trans-ure;NCI-C04955;Aids126009
CBNumber:
CB1173336
Summenformel:
C10H18ClN3O2
Molgewicht:
247.72
MOL-Datei:
13909-09-6.mol

Semustine Eigenschaften

Schmelzpunkt:
64°C (rough estimate)
Dichte
1.3346 (rough estimate)
Brechungsindex
1.5500 (estimate)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
L?slichkeit
Soluble in DMSO
Aggregatzustand
Solid
pka
10.89±0.40(Predicted)
Farbe
Light yellow to yellow
CAS Datenbank
13909-09-6
IARC
1 (Vol. Sup 7, 100A) 2012
EPA chemische Informationen
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (13909-09-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 45-46-23/24/25-36/37/38
S-S?tze: 53-22-26-36/37/39-45
RIDADR  3249
WGK Germany  3
RTECS-Nr. YS5000000
HazardClass  6.1(a)
PackingGroup  II
Giftige Stoffe Daten 13909-09-6(Hazardous Substances Data)
Toxizit?t child,LDLo,oral,5550mg/kg/30W (5550mg/kg),KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI,New England Journal of Medicine. Vol. 300, Pg. 1200, 1979.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizit?t oral Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H350 Kann Krebs verursachen. Karzinogenit?t Kategorie 1A Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Semustine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R46:Kann vererbbare Sch?den verursachen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

In October 2008, scientists of the International Agency for Research on Cancer reaffirmed the Group 1 classification ‘carcinogenic to humans’ of 20 pharmaceutical agents including semustine. Me-CCNU [1-(2-chloroethyl)-3- (4-methylcyclohexyl)-1-nitrosourea] is an alkylating agent of the nitrosourea group, used alone or in combination with other chemotherapeutic agents to treat several types of cancers, including primary and metastatic brain tumors, Lewis lung tumor, and L1210 leukemia. It has also been used to treat cancers of the digestive tract, Hodgkin lymphoma, malignant melanoma, and epidermoid carcinoma of the lung. Doses varied depending on the type of cancer and body weight of the individual. The typical oral dose was 125–200 mgm-2 body surface area, and was repeated every 6 weeks. An alternative regimen was reported to be 200–225 mg m-2 orally every 6–8 weeks. Me-CCNU is a bifunctional antineoplastic agent that undergoes spontaneous chemical decomposition, yielding electrophilic compounds and ultimately inducing alkylation and carbamoylation of cellular macromolecules, including DNA and protein.

Chemische Eigenschaften

A crystalline solid or light yellow powder.

Verwenden

Commonly used in pharmacological studies involving: • ;Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1• ;CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2• ;Investigations into its use for chemotherapy3,4

Definition

ChEBI: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group.

Allgemeine Beschreibung

Light yellow powder.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

A halogenated and nitrated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Brandgefahr

Flash point data for SEMUSTINE are not available. SEMUSTINE is probably combustible.

Sicherheitsprofil

Confirmed human carcinogen producing leukemia. Experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, intravenous, and possibly other routes. Mutation data reported. Human systemic effects by ingestion: nausea or vomiting, damage to kidney tubules and glomeruli, and hematuria (blood in the urine). When heated to decomposition it emits very toxic fumes of Cland NOx. See also N-NITROSO COMPOUNDS.

m?gliche Exposition

Semustine is chemotherapy agent; an antineoplastic agent which functions as an alkylating agent.

Carcinogenicity

1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

Versand/Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. PG II.

Inkompatibilit?ten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from strong acids, alkaline materials, strong bases. Semustine, an organic amide, reacts with azo and diazo compounds, releasing toxic gases. Amides are very weak bases but they can react as acids, forming salts. Contact with reducing agents can release flammable gases. Mixing amides with dehydrating agents such as such as phosphorus pentoxide or thionyl chloride generates the corresponding nitrile.

Waste disposal

It is inappropriate to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Semustine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Semustine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 68)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30236 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22787 58
Henan Alfa Chemical Co., Ltd

China 12004 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Zhejiang Ruixin Pharmaceutical Co., Ltd. 0578-2268782
rx2268782@163.com China 10 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865
han_yajun@dctc.daicel.com China 6791 65

13909-09-6()Verwandte Suche:


  • N-[2-CHLOROETHYL]-N'-[4-METHYLCYCLOHEXYL]-N-NITROSOUREA
  • SEMUSTINE
  • 1-(2-Chloroethyl)-1-([(4-methylcyclohexyl)amino]carbonyl)-2-oxohydrazine
  • 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-ure
  • 1-(2-Chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea
  • 1-(2-Chloroethyl)-3-(trans-4-methyl-cyclohexyl)-1-nitrosourea
  • ICIG 1110
  • icig1110
  • Lomustine, methyl-
  • Me-CCNU
  • Methyl-CCNU
  • methyl-lomustin
  • N-(2-Chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea
  • n-(2-chloroethyl)-n’-(4-methylcyclohexyl)-n-nitroso-ure
  • n-(2-chloroethyl)-n’-(trans-4-methylcyclohexyl)-n-nitrosourea
  • NCI-C04955
  • NSC 95441
  • nsc-95441
  • trans-Methyl-ccnu
  • trans-ure
  • Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-
  • Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, (E)-
  • Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans-
  • Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-
  • N-(4-METHYLCYCLOHEXYL)-N-(2-CHLOROETHYL)-N-NITROSOUREA
  • 1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosourea
  • 1-(2-Choroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
  • Aids126009
  • Aids-126009
  • Semustine,N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea
  • Semustin
  • SEMUSTINE(ME-CCNU) FACT.STANDARD
  • Semustine USP/EP/BP
  • 13909-09-6
  • C10H18ClN3O2
  • Nitroso Compounds
  • Nitrogen Compounds
  • Organic Building Blocks
  • Building Blocks
  • ATROMID
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Nitroso Compounds
  • Organic Building Blocks
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