Anti-UVRAG antibody ,Mouse monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-UVRAG antibody produced in mouse has been used in immunoprecipitation.
Allgemeine Beschreibung
Monoclonal Anti-UVRAG (mouse IgG1 isotype) is derived from the hybridoma UVRAG-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human UVRAG.
Biochem/physiol Actions
UVRAG is positive regulator of the Beclin 1- class III phosphatidylinositol 3-kinase (PI(3)KC3) complex. The tumor suppressor Beclin 1 forms a complex with PI(3)KC3, promoting autophagosome formation. UVRAG interacts with Beclin 1 through their coiled-coil domains and induces autophagy resultin in suppression of proliferation and tumorigenicity of human colon cancer cells. UVRAG is a tumor suppressor candidate.
Anti-UVRAG antibody ,Mouse monoclonal Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
