ANTI-PHOSPHO-INSULIN RECEPTOR (IR) (PTYR972) Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

The biological effects of insulin are mediated by insulin receptor (IR) and IGF-1 receptor. Insulin receptor consists of two α and two β subunits, each subunit has a tyrosine kinase domain. Signaling by IR is important in cell proliferation and metabolism of glucose. Insulin receptor activates the PI3K/Akt and the FKHR pathway, thereby regulates metabolism and insulin-dependent gene expression. Tyrosine 972 is an autophosphorylation site that is present in the juxtamembrane domain. Phosphorylation at Tyr972 is required for interaction of IR with its intracellular substrates and increases the stability of IR and substrate complexes. Overexpression of IR has been observed in breast cancer tissue and is implicated in proliferation of breast cancer cells, hyperinsulinemia and insulin resistance. IR can also bind IGF-I and IGF-II with decreased affinity
Anti-phospho-IR (pTyr⁹⁷²) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.

ANTI-PHOSPHO-INSULIN RECEPTOR (IR) (PTYR972) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ANTI-PHOSPHO-INSULIN RECEPTOR (IR) (PTYR972) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

---

• ANTI-PHOSPHO-INSULIN RECEPTOR (IR) (PTYR972)
• Anti-phospho-Insulin Receptor (IR) (pTyr972) antibody produced in rabbit
• IHormones
• Insulin and Insulin ReceptorsIslet Stem Cell Biology
• Insulin AntibodiesAntibodies for Kinase/Phosphatase Biology
• Insulin Receptor (IR)
• Alphabetical Index
• Antibodies to Hormones
• Antibodies to Other Protein/Peptide HormonesAntibodies
• Cell Biology
• Islet Stem Cell Characterization/Tracking
• Other Protein/Peptide Hormones
• Receptor Tyrosine Kinase Antibodies