Anti-NOH1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-NOX1 antibody produced in rabbit has been used in:
- Immunocytochemistry.
- Immunoprecipitation
- Immunoblotting.
Allgemeine Beschreibung
NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
Biochem/physiol Actions
NADPH oxidase 1 (NOX1) requires two cytosolic regulators NADPH oxidase activator 1(NOXA1) and NADPH oxidase organizer 1 (NOXO1) as well as Ras-related C3 botulinum toxin substrate 1 (Rac1) for its activity. NOX1 and NOX2 promote neurotoxic activation of microglia suggesting that they play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). In ALS mice deletion of either NOX1 and NOX2 gene have been shown to significantly slowed disease progression and improved survival.
Anti-NOH1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
