(-)-BLEBBISTATIN
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- CAS號:
- 856925-71-8
- 英文名:
- (-)-Blebbistatin
- 英文別名:
- CS-978;(-)-BLEBBISTATIN;(±)-Blebbistatin;(-)-Blebbistcitin;(+/-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN;Blebbistatin S enantiomer;(-)-Blebbistatin USP/EP/BP;(-)-Blebbistatin, 10 mM in DMSO;(-)-Blebbistatin *CAS#: 856925-71-8*
- 中文名:
- (-)-BLEBBISTATIN
- 中文別名:
- (-)-博氏定;(?)-布雷他汀;(-)-布雷他汀;(-)-II型肌球蛋白;(–)-BLEBBISTATIN;化合物(-)-BLEBBISTATIN;細(xì)胞抑制劑(-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN試劑;MYOSIN II抑制劑((-)-BLEBBISTATIN);(S)-3A-羥基-6-甲基-1-苯基-3,3A-二氫-1H-吡咯[2,3-B]喹啉-4(2H)-酮
- CBNumber:
- CB92129465
- 分子式:
- C18H16N2O2
- 分子量:
- 292.33
- MOL File:
- 856925-71-8.mol
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(-)-BLEBBISTATIN化學(xué)性質(zhì)
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熔點:
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210-212°C
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沸點:
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507.3±60.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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儲存條件:
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-20°C
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溶解度:
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DMSO: soluble5mg/mL
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形態(tài):
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Yellow solid
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酸度系數(shù)(pKa):
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11.15±0.20(Predicted)
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顏色:
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Light Yellow to Yellow
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(-)-BLEBBISTATIN性質(zhì)、用途與生產(chǎn)工藝
(-)-Blebbistatin ((S)-(-)-Blebbistatin)是一種細(xì)胞滲透性抑制劑，作用于非肌球蛋白IIATPase，無細(xì)胞試驗中IC50為~2 μM，不抑制肌球蛋白輕鏈激酶 (MLCK)，抑制卵裂溝的縊縮，不干擾有絲分裂或收縮環(huán)的組裝。
| Target | Value |
non-muscle myosin II ATPases
(Cell-free assay)
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0.5 μM-5 μM
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Blebbistatin抑制細(xì)胞分裂，改變魚角膜細(xì)胞的平滑運動，且抑制缺乏細(xì)絲蛋白的細(xì)胞系進(jìn)行自發(fā)起泡。Blebbistatin抑制非肌肉肌球蛋白IIA，非肌肉肌球蛋白IIB，和兔骨骼肌肌球蛋白S1的HMM片段的酶活性，而不抑制平滑肌球蛋白。Blebbistatin快速且可逆抑制Mg-ATPase活性，也抑制非肌肉肌球蛋白IIA和IIB的體外活性，而極其微弱抑制平滑肌肌球蛋白（IC50=80 μM）。Blebbistatin有效抑制Dictyostelium肌球蛋白II，但極其微弱抑制Acanthamoeba肌球蛋白II。Blebbistatin不抑制代表性的I，V，和X型肌球蛋白超家族成員。Blebbistatin不與核苷酸競爭性結(jié)合到骨骼肌肌球蛋白亞片段-1。Blebbistatin優(yōu)先結(jié)合到ATP酶，與ADP和磷酸鹽在活性位點相互作用，減慢磷釋放。Blebbistatin既不干擾肌球蛋白與肌動蛋白結(jié)合，也不干擾ATP誘導(dǎo)的肌動球蛋白解離。
Blebbistatin dose-dependently and completely relax both KCl- and carbachol-induced rat detrusor and endothelin-1-induced human bladder contraction. Pre-incubation with 10 μM blebbistatin attenuates carbachol responsiveness by 65% while blocking electrical field stimulation-induced bladder contraction reaching 50% inhibition at 32 Hz.
用途
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell
. Blebbistatin blocks both blebbing and cytokinesis at 50-100μM.
[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)
(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
(-)-BLEBBISTATIN
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-13441 | (-)-BLEBBISTATIN
(-)-Blebbistatin | 856925-71-8 | 1 mg | 283元 |
| 2025/02/08 | HY-13441 | (-)-BLEBBISTATIN
(-)-Blebbistatin | 856925-71-8 | 5mg | 720元 |
(-)-BLEBBISTATIN
生產(chǎn)廠家
856925-71-8, (-)-BLEBBISTATIN 相關(guān)搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Chiral Reagents
- Caspases/Apoptosis
- 抑制劑
- 藥靶配體
- 其他生化試劑
- 細(xì)胞生物學(xué)試劑
- 小分子抑制劑，天然產(chǎn)物
- 膜轉(zhuǎn)運
- 離子通道
- (-)-II型肌球蛋白
- (?)-布雷他汀
- (-)-布雷他汀
- (S)-(-)-BLEBBISTATIN試劑
- (S)-3A-羥基-6-甲基-1-苯基-3,3A-二氫-1H-吡咯[2,3-B]喹啉-4(2H)-酮
- 化合物(-)-BLEBBISTATIN
- (-)-博氏定
- (–)-BLEBBISTATIN
- MYOSIN II抑制劑((-)-BLEBBISTATIN)
- 細(xì)胞抑制劑(-)-BLEBBISTATIN
- 856925-71-8
- (±)-Blebbistatin
- (-)-Blebbistatin, 10 mM in DMSO
- inhibit,Myosin,Inhibitor,( ) Blebbistatin,()Blebbistatin
- (-)-Blebbistatin USP/EP/BP
- (-)-Blebbistcitin
- (S)-3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
- Blebbistatin S enantiomer
- (-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN
- (-)-Blebbistatin *CAS#: 856925-71-8*
- CS-978
- (3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
- (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem
- (S)-3a-Hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one
- 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
1,2,3,3atetrahydro3ahydroxy6methyl1phenyl4Hpyrrolo[2,3b]quinolin4one
- 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (-)-Blebbistatin
- (S)-(-)-BLEBBISTATIN
- (+/-)-BLEBBISTATIN
- 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-
- (-)-BLEBBISTATIN