奎寧定鹽酸鹽
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- CAS號:
- 6151-40-2
- 英文名:
- QUINIDINE HYDROCHLORIDE
- 英文別名:
- QUINIDINE HYDROCHLORIDE;QUINIDINE HYDROCHLORIDE MONOHYDRATE;Quinidine monohydrate hydrochloride;Quinidine monohydrochloride monohydrate;QUINIDINE HYDROCHLORIDE ISO 9001：2015 REACH;QUINIDINE HYDROCHLORIDE MONOHYDRATE CRYSTALLINE;Quinidine hydrochloride monohydrate, 10 mM in DMSO;6μ-Methoxycinchonan-9-ol hydrochloride monohydrate;Quinidine hydrochloride monohydrate technical grade;Cinchonan-9-ol,6'-methoxy-, monohydrochloride, monohydrate, (9S)- (9CI)
- 中文名:
- 奎寧定鹽酸鹽
- 中文別名:
- 奎尼丁鹽酸鹽;奎寧定鹽酸鹽;鹽酸奎尼丁一水合物;奎尼丁單鹽酸鹽一水合物;奎尼丁 鹽酸鹽 一水合物;奎尼丁鹽酸鹽一水合物,10 MM DMSO 溶液
- CBNumber:
- CB9171297
- 分子式:
- C20H27ClN2O3
- 分子量:
- 378.9
- MOL File:
- 6151-40-2.mol
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奎寧定鹽酸鹽化學性質(zhì)
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熔點:
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258-259 C
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (263.93 mM); Water: 2.5 mg/mL (6.60 mM)
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形態(tài):
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Solid
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顏色:
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White to off-white
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奎寧定鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
Quinidine hydrochloride monohydrate 是一種抗心律失常劑，也是 K+ 通道 (K+ channel) 的有效阻斷劑，其 IC50 值為 19.9 μM。Quinidine hydrochloride monohydrate 是一種有效且選擇性的細胞色素 P450db (cytochrome P450db) 抑制劑，也可用作瘧疾的研究。
IC50: 19.9 μM (K
+
channel)
Quinidine hydrochloride monohydrate blocks WT mSlo3 (K
Ca
5.1) channels with an IC
50
of 19.9±1.41?μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC
50
of 2.42±0.60?μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC
50
of 38.4±6.77?μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence.
Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side.
奎寧定鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-B1302 | 奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate | 6151-40-2 | 100mg | 500元 |
| 2025/02/08 | HY-B1302 | 奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate | 6151-40-2 | 10mM * 1mLin DMSO | 550元 |
6151-40-2, 奎寧定鹽酸鹽 相關搜索:
- Quinolines
- Inhibitors
- Heterocyclic Building Blocks
- Enzymes
- Chemical Synthesis
- Cell Signaling Enzymes
- C11 to C30
- Building Blocks
- Biochemicals and Reagents
- Application Index
- and Substrates
- Xenobiotics and Drug Metabolism
- Xenobiotics and Drug Metabolism
- Substrates
- Heterocyclic Building Blocks
- Cell Signaling Enzymes
- QuinolinesCell Signaling Enzymes
- InhibitorsBuilding Blocks
- 抑制劑
- 高端化學
- 小分子抑制劑，天然產(chǎn)物
- 小分子抑制劑
- Cell Signaling Enzymes
- Application Index
- BioChemical
- Biochemicals and Reagents
- Inhibitors
- Enzymes, Inhibitors, and Substrates
- Xenobiotics and Drug Metabolism
- C20H24N2O2HClH2O
- 奎尼丁鹽酸鹽一水合物,10 MM DMSO 溶液
- 鹽酸奎尼丁一水合物
- 奎尼丁 鹽酸鹽 一水合物
- 奎尼丁單鹽酸鹽一水合物
- 奎尼丁鹽酸鹽
- 奎寧定鹽酸鹽
- 6151-40-2
- Quinidine hydrochloride monohydrate, 10 mM in DMSO
- Cinchonan-9-ol,6'-methoxy-, monohydrochloride, monohydrate, (9S)- (9CI)
- Potassium Channel,KcsA,Quinidine hydrochloride monohydrate,Inhibitor,Parasite,inhibit
- QUINIDINE HYDROCHLORIDE ISO 9001：2015 REACH
- 6μ-Methoxycinchonan-9-ol hydrochloride monohydrate
- Quinidine monohydrochloride monohydrate
- Quinidine monohydrate hydrochloride
- QUINIDINE HYDROCHLORIDE MONOHYDRATE CRYSTALLINE
- QUINIDINE HYDROCHLORIDE MONOHYDRATE
- QUINIDINE HYDROCHLORIDE
- Quinidine hydrochloride monohydrate technical grade