硝米芬
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- CAS號(hào):
- 10448-84-7
- 英文名:
- Nitromifene
- 英文別名:
- CI628;Nitromifen;Nitromifene;1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine;1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine;Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
- 中文名:
- 硝米芬
- 中文別名:
- 硝米芬;化合物 T16330;化合物 NITROMIFENE
- CBNumber:
- CB31179337
- 分子式:
- C27H28N2O4
- 分子量:
- 444.52
- MOL File:
- 10448-84-7.mol
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硝米芬化學(xué)性質(zhì)
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熔點(diǎn):
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118-120 °C(Solv: methanol (67-56-1))
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沸點(diǎn):
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576.7±50.0 °C(Predicted)
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密度:
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1.183±0.06 g/cm3(Predicted)
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酸度系數(shù)(pKa):
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9.52±0.20(Predicted)
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硝米芬性質(zhì)、用途與生產(chǎn)工藝
Nitromifene 是一個(gè)雌激素受體 (ER) 拮抗劑。
Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase.
硝米芬
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
10448-84-7, 硝米芬 相關(guān)搜索:
- 抑制劑
- 化合物 NITROMIFENE
- 化合物 T16330
- 硝米芬
- 10448-84-7
- 1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
- Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
- CI628
- Nitromifen
- 1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine
- Nitromifene