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548-83-4

中文名稱(chēng) 高良姜素
英文名稱(chēng) Galangin
CAS 548-83-4
EINECS 編號(hào) 208-960-4
分子式 C15H10O5
MDL 編號(hào) MFCD00006833
分子量 270.24
MOL 文件 548-83-4.mol
更新日期 2024/12/30 13:10:04
548-83-4 結(jié)構(gòu)式 548-83-4 結(jié)構(gòu)式

基本信息

中文別名
3,5,7-三羥基黃酮
高良姜素
高良姜精
3,5,7-三羥基-2-苯基-4H-1-苯并呋喃-4-酮
3,5.7-三羥基黃酮
英文別名
3,5,7-trihydroxy-2-phenyl-chromen-4-one
3,5,7-TRIHYDROXYFLAVONE
GALANGIN
NORIZALPININ
3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
3,5,7-trihydroxy-flavon
3,5,7-trihydroxy-2-phenyl-4-benzopyrone
3,5,7-Trihydroxyflavone (Galangin)
3,5,7-Trihydroxyflavone,97%
GALANGIN hplc
GALANGIN WITH HPLC
2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Galengin
所屬類(lèi)別
天然產(chǎn)物:黃酮類(lèi)化合物

物理化學(xué)性質(zhì)

外觀性質(zhì)微黃色針狀結(jié)晶(乙醇), 尚易溶于乙醇及乙醚。在堿的水溶液中成黃色溶液??缮A。熔點(diǎn):214-215℃
外觀性狀淡黃色結(jié)晶粉末,易溶于乙醇、乙醚,來(lái)源于姜科植物高良姜(Alpinia officinarum Hance)根。
熔點(diǎn)214-215 °C(lit.)
沸點(diǎn)333.35°C (rough estimate)
密度1.2319 (rough estimate)
折射率1.6000 (estimate)
儲(chǔ)存條件room temp
溶解度可溶于丙酮(少許)、乙酸乙酯(少許)
酸度系數(shù)(pKa)6.32±0.40(Predicted)
形態(tài)固體
顏色淡黃色至黃色
Merck14,4339
BRN272179
InChIKeyVCCRNZQBSJXYJD-UHFFFAOYSA-N
LogP3.322 (est)
CAS 數(shù)據(jù)庫(kù)548-83-4(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
防范說(shuō)明P301+P312+P330
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類(lèi)別碼R36/37/38
安全說(shuō)明S26-S37/39
WGK Germany3
RTECS號(hào)LK9275500
海關(guān)編碼29329990

應(yīng)用領(lǐng)域

用途一
能使鼠傷寒沙門(mén)氏菌ta98和ta100發(fā)生誘變。

常見(jiàn)問(wèn)題列表

用途
高良姜是一種在高良姜、高良姜和蜂膠中發(fā)現(xiàn)的黃烷類(lèi)物質(zhì)。高良姜已被證明可以抑制雌激素受體陽(yáng)性的MCF-7人乳腺癌細(xì)胞的增殖,并延緩乳腺腫瘤的發(fā)生。
生物活性
Galangin (Norizalpinin) 是 arylhydrocarbon 受體的調(diào)節(jié)劑,同時(shí)抑制 CYP1A1 的活性。
體外研究

Galangin (Norizalpinin)?inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner.?Galangin?also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth.?Galangin?causes a potent, dose-dependent inhibition of?CYP1A1?activity, as measured by ethoxyresorufin-O-deethylase?activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that?galangin?inhibits CYP1A1?activity?in a noncompetitive manner.?Galangin?causes an increase in the level of?CYP1A1?mRNA, indicating that it may be an?agonist?of the?aryl?hydrocarbon?receptor, but it inhibits the induction of?CYP1A1?mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD).?Galangin?also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the?CYP1A1?promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.

高良姜素價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/11XW05488342高良姜素
3,5,7-trihydroxy flavone;3,5,7-trihydroxy-2-phenyl-4-benzopyrone;3,5,7-trihydroxy-2-phenyl-4h-1-benzopyran-4-one;galangin;norizalpinin
548-83-4100MG555元
2024/11/08L142233,5,7-三羥基黃酮, 97%
3,5,7-Trihydroxyflavone, 97%
548-83-425mg1159元
2024/11/08L142233,5,7-三羥基黃酮, 97%
3,5,7-Trihydroxyflavone, 97%
548-83-4100mg3224元
"548-83-4" 相關(guān)產(chǎn)品信息
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