518-75-2
中文名稱
桔霉素
英文名稱
CITRININ
CAS
518-75-2
EINECS 編號
208-257-2
分子式
C13H14O5
MDL 編號
MFCD00006912
分子量
250.25
MOL 文件
518-75-2.mol
更新日期
2025/01/25 09:07:49
518-75-2 結(jié)構(gòu)式
基本信息
中文別名
桔霉素橘霉素
桔青霉素
橘黴毒素
英文別名
4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC ACID
ANTIMYCIN
CIT
CITRININ
CITRININ, PENICILLIUM CITRINUM
(3r,4s)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carbox
(3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
,(3r-trans)-
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-
4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylicaci
6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-(3r-trans)-3h-2-benzopyran-7-carboxylicaci
8-Hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
Citriain
citrinin,antimycin
3,4-dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxobenzo(c)pyran-7-carboxylic acid
CITRININ FROM PENICILLIUM CITRINUM
Cytrinine
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-
所屬類別
原料藥：其它抗生素類藥物理化學(xué)性質(zhì)
熔點(diǎn)175°C (dec.)
熔點(diǎn)175°C (dec.)
比旋光度D18 -37.4° (c = 1.15 in alc.)
沸點(diǎn)313.38°C (rough estimate)
密度1.37
折射率1.4560 (estimate)
閃點(diǎn)2℃
儲存條件2-8°C
儲存條件2-8°C
溶解度≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
酸度系數(shù)(pKa)1.52±0.60(Predicted)
形態(tài)結(jié)晶粉末或薄片
顏色黃色
生物來源rabbit
Merck13,2351
BRN5282243
穩(wěn)定性吸濕性
CAS 數(shù)據(jù)庫518-75-2(CAS DataBase Reference)
(IARC)致癌物分類3 (Vol. 40, Sup 7) 1987
EPA化學(xué)物質(zhì)信息Citrinin (518-75-2)
安全數(shù)據(jù)
警示詞危險
危險性描述H301+H311+H331-H351
危險品標(biāo)志T
危險類別碼23/24/25-40-36/37/38
危險類別碼R23/24/25-R40
危險品運(yùn)輸編號UN 3462 6.1/PG 3
危險品運(yùn)輸編號UN 3462 6.1/PG 3
WGK Germany3
WGK Germany3
RTECS號DJ2275000
危險等級6.1(a)
包裝類別II
海關(guān)編碼29419090
毒害物質(zhì)數(shù)據(jù)518-75-2(Hazardous Substances Data)
毒性LD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)
應(yīng)用領(lǐng)域
用途一
一種真菌毒素，發(fā)現(xiàn)于谷物和使動物腎中毒的飼料中，是嚙齒類動物的制畸劑，該毒素能減少胚泡細(xì)胞數(shù)量、胚胎存活率、減輕新生兒體重及增加致命的畸形。在培養(yǎng)基中對細(xì)胞的毒性和活性氧的類別有關(guān)。激活線粒體的凋亡路徑，阻礙抗凋亡磷酸化路徑。