1568-80-5
1568-80-5 結(jié)構(gòu)式
基本信息
螺二茚滿
3,3,3',3'-四甲基螺環(huán)二酚
3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇
3,3,3',3'-四甲基-2,2',3,3'-四氫-1,1'-螺二[茚滿]-6,6'-二醇
SPIROBIINDANE
-tetrahydro-1,1'
-tetramethyl-2,2'
-spirobi[indene]-6,6'
HIV-1 integrase inhibitor 8
3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol
tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 50mg | 300元 |
| 2024/11/08 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 100mg | 500元 |
常見問題列表
HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2+ as the cationic cofactor by gel assay with IC 50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.