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ChemicalBook--->CAS DataBase List--->8048-52-0

8048-52-0

8048-52-0 Structure

8048-52-0 Structure
IdentificationMore
[Name]

ACRIFLAVINE
[CAS]

8048-52-0
[Synonyms]

2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
ACRIFLAVINE
ACRIFLAVINE BASE
ACRIFLAVINE NEUTRAL
CI 46000
CI NO 46000
EUFLAVIN
EUFLAVINE
TRYPAFLAVINE
TRYPAFLAVINE FS
XANTHACRIDINE
2,8-diamino-10-methylacridiniumchloridemixturewith2,8-diaminoacridine
3,6-diamino-10-methylacridiniumchloridemixturewith3,6-acridinediamine
3,6-diaminoacridinemixturewith3,6-diamino-10-methylacridiniumchloride
acridinium,3,6-diamino-10-methyl-,chloridemixedwith3,6-acridinediamine
angiflan
assiflavine
bialflavina
bioacridin
[EINECS(EC#)]

999-999-2
[Molecular Formula]

C27H25ClN6
[MDL Number]

MFCD00064307
[Molecular Weight]

468.98
[MOL File]

8048-52-0.mol
Chemical PropertiesBack Directory
[Appearance]

deep orange to brownish-red powder
[Melting point ]

179-181 °C
[Boiling point ]

612.69°C (rough estimate)
[density ]

1.0933 (rough estimate)
[refractive index ]

1.6000 (estimate)
[storage temp. ]

Store at -20°C
[solubility ]

H2O: soluble0.33g/mL (lit.)(lit.)
[form ]

Powder
[color ]

Deep orange to brownish-red
[Water Solubility ]

H2O: 0.33g/mL (lit.)(lit.)
[Merck ]

123
[CAS DataBase Reference]

8048-52-0(CAS DataBase Reference)
[EPA Substance Registry System]

8048-52-0(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,N
[Risk Statements ]

R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S29:Do not empty into drains .
[RIDADR ]

UN 3077 9/PG 3
[WGK Germany ]

3
[RTECS ]

AR9660000
[HS Code ]

29339900
[Safety Profile]

Poison by subcutaneous route. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. A topical antiseptic used in the treatment of gonorrhea. When heated to decomposition it emits very toxic fumes of NOx and Cl-. See also 3,6-DIAMINO-10 METHYLACRIDINIUM CHLORIDE.
Hazard InformationBack Directory
[Chemical Properties]

Acriflavine hydrochloride is deep orange to brownish-red powder
[Uses]

Acriflavine is used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.
[Uses]

Fluorescent label for high molecular weight RNA
[Biological Activity]

Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2αand thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidalantibacterial and antiviral activities.
[storage]

Store at -20°C
[Purification Methods]

Treat acriflavin twice with freshly precipitated AgOH to remove proflavine, then recrystallise it from absolute methanol [Wen & Hsu J Phys Chem 66 1353 1962]. [Beilstein 22 III/IV 218.]
Spectrum DetailBack Directory
[Spectrum Detail]

ACRIFLAVINE(8048-52-0)IR1
ACRIFLAVINE(8048-52-0)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Acriflavine neutral, 13.3-15.8% chlorine(8048-52-0)
[Sigma Aldrich]

8048-52-0(sigmaaldrich)
[TCI AMERICA]

Acriflavine  (mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine)(8048-52-0)
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