| Identification | More | [Name]
Isosorbide | [CAS]
652-67-5 | [Synonyms]
1,4:3,6-DIANHYDRO-D-GLUCITOL
1,4:3,6-DIANHYDRO-D-SORBITOL
1,4:3,6-DIANHYDROGLUCITOL
1,4:3,6-DIANHYDROSORBITOL
(3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL
DIANHYDRO-D-GLUCITOL
DIANHYDRO-D-SORBITOL
D-ISOSORBIDE
ISOSORBIDE
1,4:3,6-dianhydro-d-glucito
4:3,6-dianhydro-d-glucito
at101
d-1,4:3,6-dianhydroglucitol
devicoran
hydronol
isobide
Isosorbide,typically98%
Isosorbid
D-Glucitol, 1,4:3,6-dianhydro-
D-Glucitol, 1,4:3,6-dianhydro-(9CI) | [EINECS(EC#)]
211-492-3 | [Molecular Formula]
C6H10O4 | [MDL Number]
MFCD00064827 | [Molecular Weight]
146.14 | [MOL File]
652-67-5.mol |
| Chemical Properties | Back Directory | [Definition]
A polyol with a hydroxyl group attached to each of
two cis-oriented saturated furan rings. Intermediate
for pharmaceuticals. Combustible. | [Appearance]
off-white to light yellow or beige crystals, | [Melting point ]
60-63 °C (lit.) | [alpha ]
42 º (c=3, H2O) | [Boiling point ]
175°C/2mmHg(lit.) | [density ]
1.0945 (rough estimate) | [vapor pressure ]
0.007Pa at 20℃ | [refractive index ]
45 ° (C=5, H2O) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Crystals, Crystalline Solid or Mass | [pka]
13.17±0.40(Predicted) | [color ]
Off-white to light yellow or beige | [optical activity]
[α]20/D +45.2°, c = 3 in H2O | [Water Solubility ]
Soluble in alcohols, water and ketones. | [Sensitive ]
Hygroscopic | [Merck ]
14,5224 | [BRN ]
80510 | [InChIKey]
KLDXJTOLSGUMSJ-JGWLITMVSA-N | [LogP]
-1.39 at 20℃ | [CAS DataBase Reference]
652-67-5(CAS DataBase Reference) | [EPA Substance Registry System]
D-Glucitol, 1,4:3,6-dianhydro- (652-67-5) |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to light yellow or beige crystals, | [Uses]
D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters. | [Uses]
Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
| [Uses]
pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics. | [Brand name]
Ismotic (Alcon). | [Biological Functions]
emergency treatment of acute angle-closure glaucoma.
It should not be confused with isosorbide dinitrate, an
antianginal drug. | [Flammability and Explosibility]
Nonflammable | [Clinical Use]
Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its
ophthalmologic properties are its primary value. | [storage]
Store at -20°C |
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