| Identification | More | [Name]
Buflomedil | [CAS]
55837-25-7 | [Synonyms]
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
AURORA KA-850
BUFLOMEDIL
1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-
2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon
BufluomedilHcl
Buflomedil Hcl 35543-24-9/Base
Buflomedil (base and/or unspecified salts) | [EINECS(EC#)]
259-851-3 | [Molecular Formula]
C17H25NO4 | [MDL Number]
MFCD00242740 | [Molecular Weight]
307.38 | [MOL File]
55837-25-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
EL9885000
| [HS Code ]
29339990 |
| Hazard Information | Back Directory | [Originator]
Fonzylane,Lafon,France,1976 | [Uses]
BAN; DCF; MI. | [Definition]
ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone. | [Manufacturing Process]
Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of
chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid
bubbler and condenser. Stir to dissolve and add 27.7 g of 4-
pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to
about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about
5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again
with 150 cm3 of water. Combine the aqueous layers, drive off the traces of
chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one
hour. Cool and render alkaline by means of 60 ml of sodium hydroxide
solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether
with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50
ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter,
wash with ether and dry in a vacuum oven. 33.6 g of crude product are
obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA
carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield:
39.2%. Instantaneous melting point: 192°-193°C. | [Therapeutic Function]
Vasodilator |
|
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