| Identification | More | [Name]
4-Mercaptopyridine | [CAS]
4556-23-4 | [Synonyms]
4-MERCAPTOPYRIDINE
4-PYRIDINETHIOL
4-PYRIDYL MERCAPTAN
Pyridine-4-thiol
4-Thiopyridine
Pyridine, 4-mercapto-
Mercaptopyridine,90%
4-Pyridimethiol
4-mercapto-pyridin
4-mercatopyridine
1H-Pyridine-4-thione | [EINECS(EC#)]
224-926-1 | [Molecular Formula]
C5H5NS | [MDL Number]
MFCD00006422 | [Molecular Weight]
111.16 | [MOL File]
4556-23-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow to light yellow crystalline powder | [Melting point ]
182-189 °C | [Boiling point ]
194.0±13.0 °C(Predicted) | [density ]
1.161 (estimate) | [refractive index ]
1.5605 (estimate) | [storage temp. ]
0-6°C | [solubility ]
DMSO, Methanol | [form ]
Crystalline Powder | [pka]
pK1:1.43(＋1);pK2:8.86(0) (20°C) | [color ]
Yellow to yellow-green or brown | [InChIKey]
FHTDDANQIMVWKZ-UHFFFAOYSA-N | [Uses]
mercaptopyridine is also known as sodium pyrithione. It is a preservative that is not commoly used. | [CAS DataBase Reference]
4556-23-4(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Pyridinethiol(4556-23-4) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
UT8578000
| [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
4-Mercaptopyridine is Yellow to light yellow crystalline powder
| [Purification Methods]
Purify the thiol by dissolving ~45g in boiling H2O (100mL) (charcoal), filter and precipitate it by adding 50% aqueous NaOH (~80mL) to pH ~6. Dissolve the precipitate in EtOH, evaporate it to dryness, then crystallise it from boiling EtOH (~100mL, charcoal) to give yellow flat hexagonal plates (m 186o). It sublimes readily in vacuo. [King & Ware J Chem Soc 873 1939.] The picrate forms yellow needles from H2O with m 222o(dec). The 4-methylmercaptopyridine derivative crystallises from pet ether (m 47o , also 44-45o was reported, with a pK2 0 of 5.97) and was prepared by treatment with MeI/NaOH. Its picrate has m 2 4 5o (from H2O, MeOH or EtOH). The N-methyl-4-pyridinethiol derivative has m 168.5-170o (from EtOH), a pK2 0 of 1.30 and is soluble in CHCl3. [Albert & Barlin J Chem Soc 2384 1959, Beilstein 21 II 35, 22 III/IV 373, 22/7 V 147.] |
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