| Identification | More | [Name]
Bis(cyclohexanone)oxaldihydrazone | [CAS]
370-81-0 | [Synonyms]
BIS(CYCLOHEXANONE) OXALDIHYDRAZONE
BISCYCLOHEXANONE OXALYLDIHYDRAZONE
BIS(CYCLOHEXYLIDENE)OXALODIHYDRAZIDE
CUPFERAZONE
CUPRIZON
CUPRIZON 1
CUPRIZONE
CUPRIZONE I
CUPRIZON I
DICYCLOHEXANONE OXALYLDIHYDRAZONE
OXALIC ACID BIS(CYCLOHEXYLIDENEHYDRAZIDE)
TIMTEC-BB SBB008866
biscyclohexanone
biscyclohexanoneoxadihydrazone
Dicyclohexanoneoxalyldihydrazo
dicyclohexanoneoxalyldihydrozone
ethanedioicacid,bis(cyclohexylidenehydrazide)
Oxalybis(cyclohexylidene hydrazone)
N,N-oxalylbis(cyclohexanone hydrazone)
oxalic bis(cyclohexylidenehydrazide) | [EINECS(EC#)]
206-729-2 | [Molecular Formula]
C14H22N4O2 | [MDL Number]
MFCD00001659 | [Molecular Weight]
278.35 | [MOL File]
370-81-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
210-214 °C(lit.)
| [Boiling point ]
421.17°C (rough estimate) | [bulk density]
150kg/m3 | [density ]
1.0823 (rough estimate) | [refractive index ]
1.6200 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
acetic acid: 50mg/mL, colorless to very faintly brown | [form ]
Powder | [pka]
10.78±0.20(Predicted) | [color ]
White | [Water Solubility ]
Soluble in alcohol. Insoluble in water. | [BRN ]
2388004 | [CAS DataBase Reference]
370-81-0(CAS DataBase Reference) | [EPA Substance Registry System]
370-81-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S2:Keep out of the reach of children . | [WGK Germany ]
3
| [RTECS ]
RO2520000
| [TSCA ]
Yes | [HS Code ]
29280090 | [Safety Profile]
Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. See also
OXALATES. |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt. | [Definition]
ChEBI: Cuprizon is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid. | [Biological Activity]
Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell deaththereby leading to demyelinationastrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum. |
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