| Identification | Back Directory | [Name]
BTSA 1 | [CAS]
314761-14-3 | [Synonyms]
BTSA 1
CS-2853
BTSA 1;BTSA-1
BTSA1 >=98% (HPLC)
5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one
1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone] | [Molecular Formula]
C21H14N6OS2 | [MOL File]
314761-14-3.mol | [Molecular Weight]
430.51 |
| Chemical Properties | Back Directory | [Boiling point ]
625.2±48.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM) | [form ]
Solid | [pka]
6.52±0.40(Predicted) | [color ]
Brown to reddish brown |
| Hazard Information | Back Directory | [Biological Activity]
BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells. | [in vivo]
BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated. | [target]
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| Company Name: |
Hui Chem Co., Ltd.
|
| Tel: |
021-34799779 18918539052 |
| Website: |
http://www.huichem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|
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Tags:314761-14-3
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