| Identification | More | [Name]
(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine | [CAS]
22348-32-9 | [Synonyms]
2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-
A,A-DIPHENYL-D-PROLINOL
ALPHA,ALPHA-DIPHENYL-D-PROLINOL
(R)-1-DIPHENYL-PROLINOL
(R)-(+)-2-(DIPHENYLHYDROXYMETHYL)-PYRROLIDIN
(R)-(+)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
(R)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
R(+)-A,A-DIPHENYLPROLINOL
R-(+)-ALFA,ALFA-DIPHENYL-2-PYRROLIDINE METHANOL
(R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
(R)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
(R)-(+)-ALPHA,ALPHA-DIPHENYL-(2-PYRROLIDINYL)-METHANOL
(R)-(+)-ALPHA,ALPHA-DIPHENYLPROLINOL
(R)-(+)-DIPHENYL-2-PYRROLIDINEMETHANOL
(R)-DIPHENYLPROLINOL
(R)-(+)-DIPHENYLPYRROLIDINEMETHANOL
RDPP
(R)-(+)-alpha,alpha-diphenyl-2-pyrrolidine
(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL
(R)-(+)-A,A-DIPHENYL-2-PYRROLIDINEMETHANOL
| [EINECS(EC#)]
606-992-7 | [Molecular Formula]
C17H19NO | [MDL Number]
MFCD00077754 | [Molecular Weight]
253.34 | [MOL File]
22348-32-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to faintly yellow crystalline powder | [Melting point ]
77-80 °C
| [alpha ]
59 º (589nm, c=3, MeOH 25 ºC) | [Boiling point ]
396.54°C (rough estimate) | [density ]
1.0078 (rough estimate) | [refractive index ]
58 ° (C=2, MeOH) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
almost transparency in Chloroform | [form ]
solid | [pka]
13.15±0.29(Predicted) | [color ]
white to off-white | [optical activity]
[α]20/D +69°, c = 3 in chloroform | [BRN ]
4353363 | [InChIKey]
OGCGXUGBDJGFFY-MRXNPFEDSA-N | [CAS DataBase Reference]
22348-32-9(CAS DataBase Reference) | [NIST Chemistry Reference]
(R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
10-34 | [TSCA ]
No | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to faintly yellow crystalline powder | [Uses]
suzuki reaction | [Definition]
ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane. | [Synthesis]
Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%. |
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