| Chemical Properties | Back Directory | [Boiling point ]
649.1±55.0 °C(Predicted) | [density ]
1.340±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 50 mg/mL (149.98 mM) | [form ]
Orange to red crystalline solid. | [pka]
12.93±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3]. | [IC 50]
FGFR1: 10-20 μM (IC50) | [References]
[1] Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60. DOI:10.1126/science.276.5314.955
[2] Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4. DOI:10.1046/j.1523-1747.2000.00888.x |
|
|