| Identification | More | [Name]
tert-Butyl 3-aminopyrrolidine-1-carboxylate | [CAS]
186550-13-0 | [Synonyms]
1-BOC-3-AMINOPYRROLIDINE
1-N-BOC-3-AMINO-PYRROLIDINE
(+/-)-3-AMINO-1-BOC-PYRROLIDINE
3-AMINO-1-BOC-PYRROLIDINE
(+/-)-3-AMINO-1-N-BOC-PYRROLIDINE
3-AMINO-1-N-BOC-PYRROLIDINE
3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-AMINOPYRROLIDINE, N1-BOC PROTECTED
TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE
DL-3-Amino-1-N-Boc-Pyrrolidine 1-N-Boc-3-Aminopyrrolidine
1-TERT-BUTOXYCARBONYL-3-AMINOPYRROLIDINE
DL-3-AMINO-1-N-BOC-PYRROLIDINE
(-3-Amino-1-Boc-pyrrolidine HCl
3-Amino-1-(tert-butoxycarbonyl)pyrrolidine | [EINECS(EC#)]
624-257-9 | [Molecular Formula]
C9H18N2O2 | [MDL Number]
MFCD01861220 | [Molecular Weight]
186.25 | [MOL File]
186550-13-0.mol |
| Chemical Properties | Back Directory | [Boiling point ]
257.4±33.0 °C(Predicted) | [density ]
1.022 | [Fp ]
91°C | [refractive index ]
1.4710 | [storage temp. ]
2-8°C | [form ]
powder to lump to clear liquid | [pka]
9.55±0.20(Predicted) | [color ]
White or Colorless to Light yellow | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
186550-13-0(CAS DataBase Reference) | [Storage Precautions]
Air sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2810 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
Ⅲ | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless low melting solid or liquid | [Uses]
1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49)
To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield.
1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H).
Mass spectrum (m/z): 187 [M+H]+. | [References]
[1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37 |
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