| Identification | More | [Name]
2,2',5,5'-Tetrachlorobenzidine | [CAS]
15721-02-5 | [Synonyms]
2,2',5,5'-TETRACHLOROBENZIDINE
4,4'-DIAMINO-2,2',5,5'-TETRACHLOROBIPHENYL
1’-biphenyl)-4,4’-diamine,2,2’,5,5’-tetrachloro-(
1’-biphenyl]-4,4’-diamine,2,2’,5,5’-tetrachloro-[
2,2’,5,5’-tetrachloro-4,4’-diaminodiphenyl
2,2’,5,5’-tetrachloro-benzidin
3,3’,6,6’-tetrachlorobenzidine
4,4'-diamino-5,5',2,2'-tetrachlorobiphenyl
2,2,5,5-TETRACHLORO-4,4-DIAMINOBIPHENYL
2,2,5,5-TETRACHLOROBENZIDINE 98+%
2,2',5,5'-Tetrachloro-[1,1'-Biphenyl]-4,4'-diamine
TCB
2,2',5,5'-Tetrachlorobenzidine
2,2',5,5'-Tetrachlorobiphenyl-4,4'-diamine | [EINECS(EC#)]
239-815-3 | [Molecular Formula]
C12H8Cl4N2 | [MDL Number]
MFCD00043918 | [Molecular Weight]
322.02 | [MOL File]
15721-02-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
135-140 °C(lit.) | [Boiling point ]
477.67°C (rough estimate) | [density ]
1.5309 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
-70°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
1.58±0.13(Predicted) | [color ]
Light yellow to Yellow to Orange | [biological source]
human | [Water Solubility ]
water: soluble | [CAS DataBase Reference]
15721-02-5(CAS DataBase Reference) | [IARC]
3 (Vol. 27, Sup 7) 1987 | [EPA Substance Registry System]
15721-02-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
61 | [Safety Statements ]
53-45 | [WGK Germany ]
3
| [RTECS ]
DD1751000
| [HS Code ]
2921.59.8090 | [Safety Profile]
Suspected carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and Cl-. |
| Hazard Information | Back Directory | [Uses]
PKM1active human has been used in:
- cell-based kinase assay to study the ability of a compound to inhibit the kinase activity of PKM1.
- oxidative stress experiments on PKM2.
- Co-immunoprecipitation (Co-IP) to determine pyruvate kinase M2 (PKM2) as a novel direct binding partner of phosphoserine aminotransferase 1 (PSAT1).
| [Definition]
ChEBI: 2,2',5,5'-Tetrachlorobenzidine is a member of biphenyls and a dichlorobenzene. | [Production Methods]
2,2' ,5,5' -Tetrachlorobenzidine is made by the reduction of 2,5-dichloronitrobenzene with zinc dust and sodium hydroxide solution. The subsequent rearrangement is carried out using sulfuric acid or hydrochloric acid. The dihydrochloride melts at 230 ℃. Tetrachlorobenzidine is marketed as the free base and is used to produce yellow pigments. | [Biological Activity]
Pyruvate kinase (PK) catalyzes the dephosphorylation of phosphoenolpyruvate(PEP) into pyruvate. It is also involved in glycolysis by releasing ATP.Allosteric effects and intracellular signal transduction regulate the enzymaticactivity of PKM1. PKM1 is involved in several biological processes such asmetabolic reprogrammingand innate and acquired immune response. Itparticipates in protein interactionsprotein synthesisglycolysisandintranuclear signal transduction. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2',5,5'-Tetrachlorobenzidine(15721-02-5)MS
2,2',5,5'-Tetrachlorobenzidine(15721-02-5)1HNMR
2,2',5,5'-Tetrachlorobenzidine(15721-02-5)13CNMR
2,2',5,5'-Tetrachlorobenzidine(15721-02-5)IR1
2,2',5,5'-Tetrachlorobenzidine(15721-02-5)IR2
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