| Identification | Back Directory | [Name]
(-)-Praeruptorin A | [CAS]
14017-71-1 | [Synonyms]
Isopteryxin
Peupraerin I
2-Butenoic acid, 2-methyl-, (9R,10R)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, (2Z)- | [Molecular Formula]
C21H22O7 | [MDL Number]
MFCD23105643 | [MOL File]
14017-71-1.mol | [Molecular Weight]
386.4 |
| Hazard Information | Back Directory | [Uses]
(-)-Praeruptorin A is a nature product that could be isolated from the roots of Peucedanum praeruptorum Dunn. (-)-Praeruptorin A relaxes ileum and tracheal smooth muscles by activating NO/cGMP signaling pathway. (-)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a Ca2+-influx blocker[1]. | [References]
[1] Xu Z, et, al. (+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis. Chem Biol Interact. 2010 Jul 30;186(2):239-46. DOI:10.1016/j.cbi.2010.04.024 |
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