| Identification | Back Directory | [Name]
MOSLOFLAVONE | [CAS]
740-33-0 | [Synonyms]
5-Hydroxy-6,7-diMethoxyflavone
5-Hydroxy-6,7-diMethoxylflavone
Mosloflavone( 5-Hydroxy-6,7-dimethoxyflavone)
5-Hydroxy-6,7-diMethoxy-2-phenyl-4H-chroMen-4-one
5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl- | [Molecular Formula]
C17H14O5 | [MDL Number]
MFCD00601540 | [MOL File]
740-33-0.mol | [Molecular Weight]
298.293 |
| Chemical Properties | Back Directory | [Melting point ]
163-164℃ (chloroform , acetone ) | [Boiling point ]
508.5±50.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.32±0.40(Predicted) | [color ]
Light yellow to yellow | [biological source]
plant | [Water Solubility ]
water: slightly soluble |
| Hazard Information | Back Directory | [Uses]
Mosloflavon is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | [Definition]
ChEBI: Mosloflavone is a member of flavonoids and an ether. | [Biological Activity]
Mosloflavanone exhibits potent anti-EV71 activity by reducing visible cytopathic effects and suppressing virus replication during the initial infection phase. It also hinders the expression of the viral VP2 proteinthereby impeding viral capsid protein synthesis. AdditionallyMosloflavone demonstrates significant anti-inflammatory potential through the inhibition of TNF-α and IL-1βwith IC50 values of 16.4 μM and 6.4 μMrespectively. It shows a dose-dependent reduction in TNF-αIL-1βand iNOS levels in the supernatant of the mouse macrophage cell line J774A. This compound holds promise as a foundational element in the quest for treatments targeting inflammatory and immunomodulatory diseases. |
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