| Identification | More | [Name]
Sucrose octaacetate | [CAS]
126-14-7 | [Synonyms]
D-(+)-SACCHAROSE OCTAACETATE
D-SACCHAROSE OCTAACETATE
D-(+)-SUCROSE OCTAACETATE
FEMA 3038
OCTAACETYLSUCROSE
OCTA-O-ACETYL D-(+)-SACCHAROSE
OCTA-O-ACETYL D-(+)-SUCROSE
SACCHAROSE OCTAACETATE
.alpha.-D-Glucopyranoside,1,3,4,6-tetra-O-acetyl-.beta.-D-fructofuranosyl,tetraacetate
1,3,4,6-tetra-o-acetyl-beta-d-fructofuranosyl-alpha-d-glucopyranosidtetr
1,3,4,6-Tetra-O-acetylhex-2-ulofuranosyl 2,3,4,6-tetra-O-acetylhexopyranoside
aacetate
alpha-D-Glucopyranoside, 1,3,4,6-tetra-O-acetyl-beta-D-fructofuranosyl, tetraacetate
alpha-d-glucopyranoside,1,3,4,6-tetra-o-acetyl-beta-d-fructofuranosyl,tetra
Soa
Sucrose octa actate
SUCROSE OCTAACETATE 97+%
OCTAACETYL SUCROSE(SACCHAROSE OCTAACETATE)
D-SucroseOctoacetate,>99%
D-SucroseOctoacetate | [EINECS(EC#)]
204-772-1 | [Molecular Formula]
C28H38O19 | [MDL Number]
MFCD00006623 | [Molecular Weight]
678.59 | [MOL File]
126-14-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to creamy white powder | [Melting point ]
82-85 °C(lit.)
| [alpha ]
D25.4 +58.5° (c = 2.56 in abs alcohol) | [Boiling point ]
260 °C(lit.)
| [density ]
1.28
| [FEMA ]
3038 | [refractive index ]
60 ° (C=2, EtOH) | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Powder | [color ]
White to creamy white | [Odor]
odorless | [Odor Type]
odorless | [optical activity]
[α]22/D +58.8°, c = 2.5 in ethanol | [Water Solubility ]
SLIGHTLY SOLUBLE | [Merck ]
8881 | [BRN ]
79290 | [InChIKey]
ZIJKGAXBCRWEOL-SAXBRCJISA-N | [LogP]
3.19 | [CAS DataBase Reference]
126-14-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Sucrose, octaacetate(126-14-7) | [EPA Substance Registry System]
126-14-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
2
| [RTECS ]
WN6620000
| [F ]
3 | [HS Code ]
29400090 | [Toxicity]
LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit 5000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Sucrose octaacetate is odorless with an intensly bitter flavor influenced by food acids | [Chemical Properties]
Sucrose octaacetate occurs as white hygroscopic powder. It is
practically odorless with a bitter taste. | [Chemical Properties]
white to creamy white powder | [Uses]
Adhesive; impregnating and insulating papers; in lacquers and plastics; as a denaturant for alcohol. | [Uses]
Octa-O-acetyl D-(+)-Surcose was used in studies involving human bitter taste receptor hTAS2R46. | [Definition]
ChEBI: Sucrose octaacetate is a glycoside. | [Preparation]
May be prepared by heating sucrose, acetamide and sodium acetate; or by acetylation of sucrose using acetic anhydride, zinc chloride and acetic acid. | [Production Methods]
Sucrose octaacetate is typically produced by chemical synthesis; one
reported synthetic method is by pyridine-catalyzed acetylation of
sucrose. | [Pharmaceutical Applications]
Sucrose octaacetate is used as an alcohol denaturant in pharmaceutical
formulations. It is also used as a bittering agent, and is
incorporated into preparations intended to deter nail-biting or
thumb-sucking. | [Safety Profile]
Slightly toxic by ingestion andskin contact. A skin irritant. When heated todecomposition it emits acrid smoke and irritating vapors. | [Safety]
Sucrose octaacetate is generally regarded as safe. It is considered
slightly hazardous in cases of skin contact (irritant), ingestion, or
inhalation.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg | [storage]
Sucrose octaacetate is a stable material and should be stored in a
well-closed, airtight container. Store in a cool, dry place; moisture
may cause instability. | [Purification Methods]
After three recrystallisations from EtOH or 95% EtOH (charcoal), the m of the octaacetate rises to 88-90o, or Et2O with m 89o and [] D +58.5o (c 2.6, EtOH). It has a bitter taste. [Linstead et al. J Am Chem Soc 62 3260 1940, Lemieux & Huber J Am Chem Soc 78 4117 1956, Beilstein 17/8 V 410.] | [Regulatory Status]
GRAS listed. Approved by the FDA as both a direct and an indirect
food additive, and as a nail-biting deterrent for over-the-counter
drug products. |
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