| Identification | More | [Name]
Polaprezinc | [CAS]
107667-60-7 | [Synonyms]
POLAPREZINC
ZINC CARNOSINE
zinc l-carnosine complex
zinc n-(3-aminopropionyl)histidine
[b-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc
b-Alanyl-L-histidinato Zinc
Promac
Z 103
Zinc Carnosin
Zinc L-Carnosine
Zn Carnosine
[-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc
-Alanyl-L-histidinato Zinc
carnosine, zinc-
PepZinGI(R)
Bis[1-(3-aminopropanoyl)-L-histidine]zinc salt | [EINECS(EC#)]
600-848-7 | [Molecular Formula]
C18H26N8O6Zn | [MDL Number]
MFCD00870906 | [Molecular Weight]
515.84 | [MOL File]
107667-60-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White To Pale-Yellow Crystalline Solid | [Melting point ]
>300°C | [Boiling point ]
177.5°C | [storage temp. ]
Refrigerator | [solubility ]
Aqueous Acid (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Usage]
PepZinGI(R) is a new dietary supplement approved by the federal agency. Don`t hesitate to contact us for more information. Attributes New dietary supplement Contact | [CAS DataBase Reference]
107667-60-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Polaprezinc, a complex of zinc ion and L-carnosine, is an antiulcer agent
launched in Japan. It is effective in promoting the healing of gastric ulcers in
addition to preventing ulcer relapse. In rat studies, polaprezinc reduces the
incidence of stomach lesions induced by ethanol. No effect was seen on
ultrastructural damage or on cell proliferation and it appears that polaprezinc
combines the cytoprotective effect of zinc with the ulcer healing properties of Lcarnosine.
The in vivo antioxidative properties of polaprezinc has been suggested
to be responsible for its protective effect against gastric mucosal injury.
Recent studies revealed that polaprezinc is an activator of bone formetion and
has inhibitory effect of bone resorption. This agent is thus able to prevent the
deterioration of bone metabolism indicating its potential usefulness in the treatment
of osteoporosis. Polaprezinc has also been claimed for the prophylaxis and
treatment of alcoholic hepatopathy, viral hepatitis or other hepatopathies caused by
certain drugs, poisons and radiation. | [Chemical Properties]
White To Pale-Yellow Crystalline Solid | [Originator]
Hamari Chemicals (Japan) | [Uses]
A novel anti-gastric ulcer agent | [Uses]
anti-ulcer drug, antioxidative, | [Uses]
PepZinGI(R) is a new dietary supplement approved by the federal agency. Don`t hesitate to contact us for more information. Attributes New dietary supplement Contact | [Brand name]
Promac | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Toxicity]
LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda) |
|
|