Vilanterol Impurity 14 synthesis
- Product Name:Vilanterol Impurity 14
- CAS Number:503068-31-3
- Molecular formula:C15H23BrO2
- Molecular Weight:315.25
Yield:503068-31-3 600 mg
Reaction Conditions:
with tetrabutylammomium bromide;sodium hydroxide in water at 20; for 16 h;
Steps:
4.2
100 mL of a one-necked flask at room temperature to the compound 4 - 1 (610 mg, 4 mmol) of 1,6-dibromohexane(1.94 g, 8 mmol) added in the solution tetrabutyl ammonium bromide (260 mg, 0.8 mmol) and 50% sodium hydroxide solution (1.6 g, 40 mmol), the reaction 16 h. Add dichloromethane (50 ml), it with water (50 ml) and saturated salt water (50 ml) . The organic phase drying, filtering, concentrated. Silica gel column (petroleum ether/ethyl acetate=10/1) to obtain the pale yellow oily product 600 mg.
References:
CN107188865,2017,A Location in patent:Paragraph 0093; 0096; 0097
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