(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate synthesis
- Product Name:(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate
- CAS Number:1499-56-5
- Molecular formula:C6H11NO3
- Molecular Weight:145.16
74844-91-0
413 suppliers
$5.00/5g
1499-56-5
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$40.00/100mg
Yield: 100%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;dichloromethane at 20; for 4 h;
Steps:
1
A solution of 4.0 N HCl in dioxane (50 mL) was added to a solution of commercially available 4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (30 g, 206 mmol) in dichloromethane (200 mL). After the reaction mixture was stirred at room temperature for 4 hours, it was concentrated to get a quantitative yield of crude intermediate XI, which was used in the next step without further purification.
References:
TaiGen Biotechnology Co., Ltd. US2008/108632, 2008, A1 Location in patent:Page/Page column 20
67-56-1
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51-35-4
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$6.00/5g
1499-56-5
43 suppliers
$40.00/100mg
51-35-4
871 suppliers
$6.00/5g
1499-56-5
43 suppliers
$40.00/100mg
67-56-1
774 suppliers
$7.29/5ml-f
2584-71-6
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$6.00/1g
1499-56-5
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$40.00/100mg
67-56-1
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3398-22-9
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$28.00/250mg
1499-56-5
43 suppliers
$40.00/100mg