trans-2-Aminocyclopentanol hydrochloride synthesis
- Product Name:trans-2-Aminocyclopentanol hydrochloride
- CAS Number:68327-11-7
- Molecular formula:C5H12ClNO
- Molecular Weight:137.61
![Carbamic acid, N-[(1R,2R)-2-hydroxycyclopentyl]-, phenylmethyl ester](/CAS/20200611/GIF/672310-36-0.gif)
672310-36-0
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68327-11-7
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Yield:68327-11-7 79.2%
Reaction Conditions:
Stage #1: (R,R)-2-N-benzyloxycarbonylaminocyclopentanolwith hydrogen;5%-palladium/activated carbon in methanol at 50; under 15001.5 Torr; for 3 h;
Stage #2: with hydrogenchloride in methanol;water; pH=3;
Steps:
16 Example 16; Synthesis of (R,R)-2-aminocyclopentanol hydrochloride
To a 100-mL autoclave were added 15 g (70.7 mmol) of (R,R)-2-benzyloxycarbonylaminocyclopentanol and 0.3 g of 5% palladium-carbon, then 45 mL of degassed methanol were added thereto in a nitrogen atmosphere and the mixture was stirred at 50°C for 3 hours under 2 MPa of hydrogen pressure. The palladium-carbon was filtered off using Celite and concentrated hydrochloric acid was added to filtrate until the pH reached 3. The aqueous layer was concentrated to give 7.9 g of the title compound (hydrochloride). The yield was 79.2%
References:
EP1398310,2004,A1 Location in patent:Page 17
![Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/GIF/454170-16-2.gif)
454170-16-2
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68327-11-7
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285-67-6
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68327-11-7
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![Carbamic acid, N-[(1R,2R)-2-(phenylmethoxy)cyclopentyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1186017-97-9.gif)
1186017-97-9
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68327-11-7
167 suppliers
$9.00/250mg