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ChemicalBook CAS DataBase List TEZAMPANEL
154652-83-2

TEZAMPANEL synthesis

3synthesis methods
Ethyl (3S,4aR,6S,8aR)-6-(hydroxymethyl)-2-(methoxycarbonyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate

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TEZAMPANEL

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) -78 deg C, 45 min
2: NaH / tetrahydrofuran / 1.) r.t., 30 min, 2.) 0 deg C, 45 min

References:

Ornstein, Paul L.;Augenstein, Nancy K.;Arnold, M. Brian [Journal of Organic Chemistry,1994,vol. 59,# 25,p. 7862 - 7869]

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