ChemicalBook CAS DataBase List Tetrahydrofuran-3-yl)methanamine

Tetrahydrofuran-3-yl)methanamine synthesis

5synthesis methods

Product Name:Tetrahydrofuran-3-yl)methanamine
CAS Number:165253-31-6
Molecular formula:C5H11NO
Molecular Weight:101.15

(TETRAHYDROFURAN-3-YL)METHANAMINE,has been achieved through Michael addition reaction of nitromethane to diethyl maleate in 6 steps with 45.5% total yield.

79710-86-4
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165253-31-6
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Yield:165253-31-6 99.5%

Reaction Conditions:

with ammonia;hydrogen in methanol at 60; under 30003 Torr; for 12 h;Pressure;Reagent/catalyst;Temperature;

Steps:

3 Synthesis of 3-aminomethyltetrahydrofuran:

Tetrahydrofuran-3-carboxaldehyde (100.12 g, 1.0 mol), Raney Ni (20.02 g) and 15% ammonia were added to the reactorMethanol solution (340 g, 3.0 mol), then 4 MPa of H2, stirred at 60 oC for 12 h, cooled to room temperature, slowlyThe mixture was filtered off and the catalyst was filtered off. The filtrate was concentrated in vacuo to give 100.64 g of 3-aminomethyltetrahydrofuran in a yield of 99.5%.

References:

CN107501213,2017,A Location in patent:Paragraph 0020; 0022; 0024; 0026; 0028; 0030; 0032; 0034

14631-44-8 Synthesis