ChemicalBook CAS DataBase List (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL synthesis

7synthesis methods

Product Name:(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
CAS Number:14774-37-9
Molecular formula:C6H12O2
Molecular Weight:116.16

96835-17-5
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$19.00/1g

14774-37-9
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$5.00/1g

Yield:14774-37-9 96%

Reaction Conditions:

Stage #1: ethyl tetrahydro-2H-pyran-4-carboxylatewith lithium aluminium tetrahydride in tetrahydrofuran at 0; for 1 h;
Stage #2: with water;sodium hydroxide in tetrahydrofuran;ethyl acetate; for 0.5 h;

Steps:

1.1

Ethyl tetrahydro-2H-pyran-4-carboxylate (5.0 g, 34.7 mmol) was added to a stirred solution of LiAlH4 (4.0 g, 104 mmol) in THF (100 mE) at 0° C. and the reaction mixture was stirred for 1 h. Ethyl acetate (20 mE) was added dropwise to the reaction mixture followed by addition of 10% aq.NaOH and the resulting mixture was stirred for additional 30 mm. Reaction mass was filtered through Celite and the filtrate was concentrated under reduced pressure to give (tetrahydro-2H-pyran-4-yl)methanol (9) as a colorless oil. Yield (3.9 g, 96%); ‘H NMR (400 MHz, DMSO-d5) δ 4.46 (bs, 1H), 3.82 (dd, J=i0.8, 8.0 Hz, 2H), 3.25-3.22 (m, 4H), 1.62-1.52 (m, 3H), 1.18-1.04 (m, 1H).

References:

US2014/275043,2014,A1 Location in patent:Paragraph 0415; 0416

110238-91-0 Synthesis