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ChemicalBook CAS DataBase List Temozolomide
85622-93-1

Temozolomide synthesis

4synthesis methods
The synthesis of temozolomide involves several steps. First, 5-Amino-4-imidazolecarboxamide is diazotized using nitrite. Then, the diazotized compound is reacted with methyl isocyanate in dichloromethane. This reaction leads to the cyclization of the compound, ultimately resulting in the formation of temozolomide.
-

Yield:85622-93-1 98.6%

Reaction Conditions:

with hydrogenchloride;lithium hydroxide monohydrate;glacial acetic acid at 20;

Steps:

17-21 Example 17

At room temperature, compound I-3 (0.88g, 5.0mmol) was dissolved in a mixed solution of glacial acetic acid (11ml) and concentrated hydrochloric acid (22ml), and the reaction was carried out at room temperature. After the reaction was detected, the reaction solution was cooled to -5°C and stirred The solid was precipitated, filtered, and the filter cake was added to DMSO (5ml) for slurrying, filtered, and the filter cake was washed with ethanol (5ml×2) The obtained filter cake is a white light powder solid and is temozolomide, Yield 98.6%, purity 99.89%.

References:

CN114591247,2022,A Location in patent:Paragraph 0110-0120

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