Sulbactam Impurity 8 synthesis
- Product Name:Sulbactam Impurity 8
- CAS Number:75527-88-7
- Molecular formula:C8H10BrNO5S
- Molecular Weight:312.14
7732-18-5
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76646-91-8
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Yield:-
Reaction Conditions:
with sodium hydrogen sulfate in sodium hydrogencarbonate;ethyl acetate;
Steps:
1 6-alpha-Bromopenicillanic Acid 1,1-Dioxide
EXAMPLE 1 6-alpha-Bromopenicillanic Acid 1,1-Dioxide To 6,6-dibromopenicillanic acid 1,1-dioxide (117.3 g, 0.3 mole), stirring in a mixture of H2 O (600 mL) and ethyl acetate (400 mL), was added in portions NaHCO3 (75.6 g, 0.9 mole) and then NaHSO3 (37.5 g, 0.36 mole). After stirring 1 hour, the pH was adjusted from 3.7 to 1.5 with concentrated HCl. The aqueous layer was separated and extracted 1*400 mL with fresh ethyl acetate. The combined organic layers were backwashed with brine, dried and evaporated to yield title product as a solid; 72 g (76.7%); m.p. 136°-137°, pnmr/D2 O-NaHCO3 /delta: 1.48 (s, CH3), 1.62 (s, CH3), 4.28 (s, C.3--H), 5.12 (d, J=1.7, C.6--H), 5.37 (d, J=1.7, C.5--H).
References:
US4468351,1984,A
76646-91-8
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$165.00/25mg
75527-88-7
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![[2S-(2alpha,5alpha,6alpha)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid](/CAS/GIF/24138-28-1.gif)
24138-28-1
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75527-88-7
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76646-91-8
71 suppliers
$165.00/25mg
68373-14-8
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$5.00/100mg
75527-87-6
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$460.00/10mg
75527-88-7
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