Selumetinib synthesis
- Product Name:Selumetinib
- CAS Number:606143-52-6
- Molecular formula:C17H15BrClFN4O3
- Molecular Weight:457.68
606093-58-7
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606143-52-6
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Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 5 h / 30 - 35 °C
1.2: 0.75 h / 10 - 20 °C
2.1: toluene-4-sulfonic acid / acetonitrile / 2.25 h / 20 - 65 °C
2.2: 0.5 h
2.3: 0.33 h / 45 - 50 °C
3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.17 h / 15 - 20 °C
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 42 h / 15 - 20 °C
5.1: sodium hydroxide; water / tetrahydrofuran / 12.17 h / 25 - 30 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.17 h / 25 - 30 °C
6.2: 24 h / 25 - 30 °C
7.1: hydrogenchloride / water; ethanol / 24 h / 25 - 30 °C
References:
SUN PHARMACEUTICAL INDUSTRIES LIMITED;SAINI, Anil;KAZI, Muddassar Ajij;KHANNA, Mahavir Singh;PRASAD, Mohan WO2018/65924, 2018, A1
![Methyl 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylate](/CAS/GIF/606144-02-9.gif)
606144-02-9
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$505.22/5MG
606143-52-6
324 suppliers
$25.00/10mg