(S)-7-(BOC-AMINO)-3-(Z-AMINO)HEPTANOIC ACID synthesis
- Product Name:(S)-7-(BOC-AMINO)-3-(Z-AMINO)HEPTANOIC ACID
- CAS Number:957494-09-6
- Molecular formula:C20H30N2O6
- Molecular Weight:394.46
![Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (3S)-](/CAS/20200611/GIF/191401-90-8.gif)
191401-90-8
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957494-09-6
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Yield:957494-09-6 100%
Reaction Conditions:
with lithium hydroxide in 1,4-dioxane at 0 - 20; for 1 h;
Steps:
408.3
Methyl (3 S )-3 -(benzyloxycarbonylamino)-7 -(tert-butoxycarbonylamino)heptanoate (1.4341g, 3.511 mmol) was dissolved in 1,4-dioxane (20 mL), and lithium hydroxide (10 mmol) was added at 0°C. The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was cooled to 0°C and acidified with 1.0 M HC1. The resultant white precipitate was extracted with iPrOAc, dried with MgSO4, filtered, and concentrated to afford (3S)-3-(benzyloxycarbonylamino)-7-(tert-butoxycarbonylamino)heptanoic acid (1.405 g, 100%), which was used without further purification.
References:
WO2017/84630,2017,A1 Location in patent:Paragraph 001101
2389-60-8
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957494-09-6
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