ChemicalBook CAS DataBase List (S)-4-Chloro-3-hydroxybutyronitrile

(S)-4-Chloro-3-hydroxybutyronitrile synthesis

11synthesis methods

Product Name:(S)-4-Chloro-3-hydroxybutyronitrile
CAS Number:127913-44-4
Molecular formula:C4H6ClNO
Molecular Weight:119.55

67843-74-7
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143-33-9 Synthesis

143-33-9
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127913-44-4
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$5.00/5g

Yield:127913-44-4 84.9%

Reaction Conditions:

with citric acid in water; pH=7.5 - 8.7 at 22 - 25; for 7 - 23 h;Product distribution / selectivity;Industry scale;

Steps:

1
3. 75 L of water was added to (S)-epichlorohydrin (99. 3% ee), and while stirring 4. 76 kg of 25% aqueous sodium cyanide solution and 3. 30 kg of 50% aqueous citric acid solution were dropped for 1 h 50 min to the solution under maintaining the reaction condition to pH 7. 9~8. 2 and 22~25C. After additional 10h stirring, 0. 7 kg of sodium chloride was added and dissolved. The resulting solution was extracted with 20 L of ethyl acetate. 0. 2 Kg of anhydrous sodium sulphate was added to the ethyl acetate layer, and then the solution was stirred for 30 min and filtered. The ethyl acetate was evaporated under reduced pressure, and the residue was distilled with thin film distillator (110 C/1 mbar) to give 1. 77 kg of the targeted compound (yield 91. 3%, chemical purity 99. 1%). Optical purity (GC) = 99. 3% ee In the same manner as described in the Experimental Example l, the reaction was performed under various conditions summarized in Table 1

References:

RSTECH CORPORATION WO2005/87715, 2005, A1 Location in patent:Page/Page column 9-10

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773837-37-9 Synthesis