(R)-4-benzyl-2-hydroxymethylpiperazine synthesis
- Product Name:(R)-4-benzyl-2-hydroxymethylpiperazine
- CAS Number:149715-46-8
- Molecular formula:C12H18N2O
- Molecular Weight:206.28
76315-01-0
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149715-46-8
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, pentafluorophenol, 2.) Et3N / 1.) dichloromethane, RT, 3 h, 2.) dichloromethane, RT, 20 h
2: 1.) SOCl2, 2.) aq. NH3 / 1.) methanol, RT, 2 h, 2.) methanol
3: 91 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
References:
Naylor;Judd;Lloyd;Scopes;Hayes;Birch [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2075 - 2083]
149648-97-5
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149715-46-8
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137442-19-4
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![L-Serine, N-[N-[(1,1-dimethylethoxy)carbonyl]-N-(phenylmethyl)glycyl]-, methyl ester (9CI)](/CAS/20210111/GIF/149648-96-4.gif)
149648-96-4
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149715-46-8
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366003-57-8
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149715-46-8
39 suppliers
$270.31/250mg