(R)-3-Methylmorpholine synthesis
- Product Name:(R)-3-Methylmorpholine
- CAS Number:74572-04-6
- Molecular formula:C5H11NO
- Molecular Weight:101.15
119844-67-6
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Yield:74572-04-6 75%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 16 h;
Steps:
General Procedure for synthesis of 5:
General procedure: LAH (2 equiv.) in THF (100 mL) was cooled to 0oC inan ice bath under nitrogen. A solution of 4 (1 equiv.) in THF (20 mL) was added dropwise, and the resulting solution was stirred at RT for 16 hrs. The reaction mixture was cooled to 0oC andcarefully quenched with water (2 mL), 2 N NaOH (2 mL) and water (8 mL). The resulting slurrywas stirred at RT for 1 h and filtered through Celite. The filter cake was washed with ethylacetate and discarded. The filtrate was dried (Na2SO4), separated and concentrated to afford 5 asa colorless oil.
References:
Dugar, Sundeep;Sharma, Amit;Kuila, Bilash;Mahajan, Dinesh;Dwivedi, Sandeep;Tripathi, Vinayak [Synthesis,2014,vol. 46,art. no. 46] Location in patent:supporting information
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![Morpholine, 4-[(4-methoxyphenyl)methyl]-3-methyl-, (3R)-](/CAS/20210305/GIF/954133-47-2.gif)
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74572-04-6
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122116-12-5
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74572-04-6
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