(R)-3-Methylmorpholine hydrochloride synthesis
- Product Name:(R)-3-Methylmorpholine hydrochloride
- CAS Number:953780-78-4
- Molecular formula:C5H12ClNO
- Molecular Weight:137.61
![Morpholine, 4-[(4-methoxyphenyl)methyl]-3-methyl-, (3R)-](/CAS/20210305/GIF/954133-47-2.gif)
954133-47-2
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Yield:953780-78-4 74%
Reaction Conditions:
Stage #1: (R)-4-(4-methoxybenzyl)-3-methylmorpholinewith carbonochloridic acid 1-chloro-ethyl ester in 1,2-dichloro-ethane at 80; for 6 h;
Stage #2: with methanol at 80; for 1 h;
Steps:
8
(3R) 3-Methvlmorpholine hydrochloride; 1-Chloroethyl chloroformate (46 g, 322 mmol) was added to a solution of (5R)-4-(4-methoxybenzyl)-5-methylmorpholine (17.8 g, 80.3 mmol) in 1,2-dichloroethane (180 ml) and the mixture was stirred for 6 hours at 80 0C. The solvent was evaporated under reduced pressure and a methanol (180 ml) solution of the residue was stirred for one hour at 80 0C. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate and dried to afford (3R)-3-methylmorpholine hydrochloride (8.2 g, 59.6 mmol, 74 %) as white crystals.
References:
WO2007/119463,2007,A1 Location in patent:Page/Page column 197; 198
74571-98-5
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953780-78-4
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120800-86-4
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![3-Morpholinone, 4-[(4-methoxyphenyl)methyl]-5-methyl-, (5R)-](/CAS/20200515/GIF/570398-22-0.gif)
570398-22-0
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953780-78-4
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