ChemicalBook CAS DataBase List QUINOXALINE, 2,3-DICHLORO-6-(TRIFLUOROMETHYL)-

QUINOXALINE, 2,3-DICHLORO-6-(TRIFLUOROMETHYL)- synthesis

5synthesis methods

Product Name:QUINOXALINE, 2,3-DICHLORO-6-(TRIFLUOROMETHYL)-
CAS Number:55686-95-8
Molecular formula:C9H3Cl2F3N2
Molecular Weight:267.03

1,4-Dihydro-6-(trifluoromethyl)quinoxaline-2,3-dione

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QUINOXALINE, 2,3-DICHLORO-6-(TRIFLUOROMETHYL)-

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Yield:55686-95-8 89%

Reaction Conditions:

with trichlorophosphateReflux;

Steps:

23.2

Step 2 2,3-Dichloro-6-(trifluoromethyl)quinoxaline A 100 mL round bottom flask was charged with 6-(trifluoromethyl)-1,4-dihydroquinoxaline-2,3-dione (7.0 g, 36 mmol) and phosphorus oxychloride (16 mL). The resulting mixture was stirred overnight at reflux. Reaction progress was monitored by TLC (EtOAc/Petroleum ether=1:10). Work-up: the reaction mixture was cooled to room temperature and cautiously poured into ice water. The solid was collected by filtration and re-dissolved in EtOAc (150 mL) then washed with brine (100 mL), dried over anhydrous Na₂SO₄, and concentrated in vacuo, to afford 7.4 g (89%) of the product as light yellow solid.

References:

US2010/120741,2010,A1 Location in patent:Page/Page column 29-30

55687-31-5
13 suppliers
$533.00/5g

55686-95-8
16 suppliers
inquiry

References