Quinazoline synthesis
- Product Name:Quinazoline
- CAS Number:253-82-7
- Molecular formula:C8H6N2
- Molecular Weight:130.15
![2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE](/CAS/GIF/1904-65-0.gif)
1904-65-0
24 suppliers
inquiry
253-82-7
153 suppliers
$11.00/1g
Yield:253-82-7 78%
Reaction Conditions:
with [Au11(PPh3)8Cl2]Cl;trimethylamine-N-oxide in toluene at 100; for 20 h;Inert atmosphere;Schlenk technique;
Steps:
Oxidative dehydrogenation of indoline:
General procedure: In a 2-neck RBF, 1 (20 mg, 0.0005 mmol) and TMNO (45 mg, 0.6 mmol) were suspended in toluene (4 mL) and to this solution indoline (60 mg, 0.5 mmol) was added. The reaction mixture was then heated to 100 oC for 20 h and it was filtered and solvent evaporated. The crude product obtained was purified by column chromatography using hexane/ethylacetate (7:1) as eluent to give pure indole (47 mg, 79%). A similar procedure was used for the other indolines and N-heterocycles.
References:
Kumaran, Elumalai;Leong, Weng Kee [Tetrahedron Letters,2018,vol. 59,# 44,p. 3958 - 3960] Location in patent:supporting information
5190-68-1
185 suppliers
$16.00/500mg
253-82-7
153 suppliers
$11.00/1g
124-38-9
129 suppliers
$175.00/23402
4403-69-4
111 suppliers
$9.00/1g
253-82-7
153 suppliers
$11.00/1g
1904-64-9
1 suppliers
inquiry
271-58-9
110 suppliers
$13.00/250mg
253-82-7
153 suppliers
$11.00/1g