Pyrimidine, 2-methyl-4-(1-piperazinyl)- (9CI) synthesis
1synthesis methods
- Product Name:Pyrimidine, 2-methyl-4-(1-piperazinyl)- (9CI)
- CAS Number:131816-67-6
- Molecular formula:C9H14N4
- Molecular Weight:178.23
Yield:-
Reaction Conditions:
in tetrahydrofuran;
Steps:
1.c c
c 2-Methyl-4-piperazino-pyrimidine 13 g of 4-chloro-2-methyl-pyrimidine were dissolved in 200 ml of tetrahydrofuran, and 17.5 g of piperazine were added. The reaction mixture was refluxed for 24 h. The precipitated piperazine hydrochloride was filtered off with suction and washed with tetrahydrofuran. Concentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine, which was reacted without further purification.
References:
US5138058,1992,A