pyrazine-2,5-dicarbaldehyde synthesis
- Product Name:pyrazine-2,5-dicarbaldehyde
- CAS Number:77666-94-5
- Molecular formula:C6H4N2O2
- Molecular Weight:136.11
79068-45-4
2 suppliers
inquiry
77666-94-5
33 suppliers
inquiry
Yield: 85%
Reaction Conditions:
with manganese(IV) oxide in 1,4-dioxane at 96; for 0.75 h;Inert atmosphere;
Steps:
Pyrazine-2,5-dialdehyde (1):
To a suspension of compound 8 (2.0 g, 14.27 mmol) in dry 1,4-dioxane (100 mL) was added activated MnO2 (6.0 g, 69.00 mmol) and the resulting mixture was heated at 96 °C under N2 atm for 45 min. It was filtered through sintered glass and the residue was washed by chloroform (100 mL). The combined filtrate was concentrated under reduced pressure to get the title compound 1 (1.65 g, 85%) as a light yellow solid. Mp: 118-119 °C (lit. m.p.: 124-125 °C).3 1H NMR (300 MHz, CDCl3): d 10.23 (s, 2H), 9.30 (s, 2H). 13C NMR (75 MHz, CDCl3): d 191.8, 148.7, 143.4. HRMS (DCI+CH4) Calcd. for C6H5N2O2 [M+H]+: 137.0351. Found: 137.0326.
References:
Das, Sajal Kumar;Frey, Joseph [Tetrahedron Letters,2012,vol. 53,# 30,p. 3869 - 3872] Location in patent:supporting information; experimental part
![Pyrazine, 2,5-bis[(1E)-2-phenylethenyl]-](/CAS/20210305/GIF/21899-24-1.gif)
21899-24-1
0 suppliers
inquiry
77666-94-5
33 suppliers
inquiry
40155-45-1
0 suppliers
inquiry
77666-94-5
33 suppliers
inquiry
123-32-0
514 suppliers
$6.00/5g
77666-94-5
33 suppliers
inquiry
123-32-0
514 suppliers
$6.00/5g
77666-94-5
33 suppliers
inquiry
50866-30-3
102 suppliers
$27.00/250mg
5780-66-5
176 suppliers
$17.00/100mg