Propionic acid hydrazide synthesis
- Product Name:Propionic acid hydrazide
- CAS Number:5818-15-5
- Molecular formula:C3H8N2O
- Molecular Weight:88.11
105-37-3
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5818-15-5
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Yield: 54%
Reaction Conditions:
with hydrazine hydrate in ethanol at 90; for 8 h;
Steps:
16.1 Step 1) propionohydrazide
[368] To a mixture of ethyl propionate (10 g, 97.9 mmol) in 25 mL of anhydrous EtOH was added hydrazine hydrate (4.5 mL, 93.0 mmol, 80%). The mixture was refluxed at 90 °C for 8 hours, then cooled down to rt and concentrated in vacuo to give the title compound as a white solid (4.37 g, 54%). MS (ESI, pos. ion) m/z: 89.2 [M+H]+.
References:
SUNSHINE LAKE PHARMA CO., LTD.;CALITOR SCIENCES, LLC;XI, Ning;WANG, Tingjin;FENG, Xuejin;WU, Shuang;ZHANG, Tao;WANG, Liang WO2016/149160, 2016, A1 Location in patent:Paragraph 368
554-12-1
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5818-15-5
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802294-64-0
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5818-15-5
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79-05-0
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$6.00/25g
5818-15-5
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105-37-3
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1528-34-3
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5818-15-5
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